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lung cancer

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    553
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    TargetMol | Inhibitors_Agonists
Gefitinib
ZD1839
T1181184475-35-2
Gefitinib (ZD1839) is an EGFR first-generation inhibitor with oral activity that inhibits the EGFR 19 Del and L858R mutations. Gefitinib has antitumor activity and is used for the treatment of EGFR-mutated non-small-cell lung cancers. Gefitinib administration RESULTS in the development of the EGFR C797S resistance mutation.
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TargetMol | Inhibitor Hot
NNK
Nicotine-derived nitrosamine ketone
T2053364091-91-4
NNK is a nicotinic nitrosylated derivative. It activates ERK1 2 and PKCα, and activates Bcl2 phosphorylation at Ser70, as well as c-Myc at Thr58 and Ser62.It can be used to construct mouse models of lung cancer, as well as to induce proliferation and survival of human lung cancer cells.
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TargetMol | Inhibitor Hot
bda-366
T67781909226-00-1
BDA-366, a potent Bcl2 antagonist, selectively binds the Bcl2-BH4 domain with high affinity (Ki = 3.3 nM), inducing a conformational change that nullifies its antiapoptotic function, thereby transforming it into a pro-apoptotic entity. This compound effectively suppresses lung cancer cell growth[1].
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TargetMol | Inhibitor Sale
Agrimol B
T4S117355576-66-4
1. Agrimol B is a main active ingredient isolated from Agrimonia pilosa Ledeb.
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VX-984
M9831
T110671476074-39-1
VX-984 (M9831) is an oral, selective DNA-PK inhibitor that can cross the blood-brain barrier. VX-984 inhibited the conjugation of non-homologous terminal NHEJ and acted on DSBs to break DNA double strand. VX-984 is commonly seen in glioblastoma (GBM) and non-small cell lung cancer (NSC-LC) studies.
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10-14 weeks
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TargetMol | Inhibitor Hot
Osimertinib
Mereletinib, AZD-9291
T24901421373-65-0
Osimertinib (AZD-9291) is an EGFR third-generation inhibitor that inhibits the T790M resistance mutation produced by second-generation EGFR inhibitors with irreversible and oral activity. Osimertinib has antitumor activity for the treatment of EGFR-mutated non-small-cell lung cancer.
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TargetMol | Inhibitor Hot
WZB117
T70181223397-11-2
WZB117 is a Glucose Transporter 1 (GLUT1) inhibitor. when IC50 of WZB117 approximate 10 μM, it inhibits lung cancer A549 cells and breast cancer MCF7 cells proliferation.
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TargetMol | Inhibitor Hot
Valproic Acid
VPA, Sodium valproate, Depakine, 2-Propylvaleric Acid, 2-Propylpentanoic Acid
T706499-66-1
Valproic Acid (2-Propylpentanoic Acid) is an HDAC inhibitor that inhibits HDAC1 activity, induces HDAC2 degradation, and is orally active. Valproic Acid can be used in epilepsy and bipolar disorder research.
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TargetMol | Inhibitor Hot
Amivantamab
JNJ-61186372, JNJ61186372, JNJ 61186372
T771102171511-58-1
Amivantamab (JNJ-61186372) is a humanized antibody that recognizes epidermal growth factor receptor (EGFR) and MET proto-oncogene (MET), with anticancer and anti-tumor activities, preventing ligand binding to EGFR and MET and receptor dimerization that inhibits downstream signal transduction. Amivantamab can induce Fc-dependent endocytosis of macrophages and antibody-dependent cytotoxicity of natural killer cells, and can be used to study metastatic non-small cell lung cancer.
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7-10 days
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TargetMol | Inhibitor Hot
MMP-9-IN-1
T8310502887-71-0
MMP-9-IN-1 is an inhibitor of specific matrix metalloproteinase-9 (MMP-9).
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TargetMol | Inhibitor Hot
Nivolumab
T9907946414-94-4
Nivolumab is a monoclonal antibody, a humanized IgG4 antibody to PD-1. Nivolumab has antitumor activity and is used in the treatment of melanoma, non-small cell lung cancer, renal cell carcinoma and others.
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TargetMol | Inhibitor Hot
divarasib
GDC-6036
T99722417987-45-0
Divarasib (GDC-6036) (GDC-6036) is an investigational, oral, high-potency and selective KRAS G12C inhibitor with an IC50 of < 0.01 μM. Divarasib irreversibly locks KRAS G12C oncoprotein in an inactive state and inhibits tumor cell growth. It is being investigated for use in solid tumors, including non-small cell lung and colorectal cancers and other types of cancer.
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TargetMol | Inhibitor Hot
Wighteone
Erythrinin B, 6-Isopentenylgenistein
TN525451225-30-0
Wighteone (Erythrinin B) is a small molecule compound derived from Genista ephedroides with potential antifungal and anticancer activity against EGFR L858R T790M mutant non-small cell lung cancer.
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7-10 days
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TargetMol | Inhibitor Hot
KRAS G12C inhibitor 16
T117702349392-79-4In house
KRAS G12C inhibitor 16 is a potent inhibitor of KRAS G12C.
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8-10 weeks
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mk-8033 hydrochloride
T120681283000-43-0In house
MK-8033 hydrochloride is an effective and orally active dual inhibitor of ATP competitive c-Met Ron, with 1 nM for c-Met and 7nM for Ron IC50. MK-8033 hydrochloride has a high affinity for activated kinase conformation, and is suitable for the study of breast cancer, bladder cancer, and non-small cell lung cancer (NSCLC).
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6-8 weeks
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OTS186935 FA
OTS186935 FA(2093400-18-9 Free base)
T12344L1 In house
OTS186935 FA is a protein methyltransferase SUV39H2 inhibitor.OTS186935 FA inhibits tumor growth in MDA-MB-231 breast cancer cells and A549 lung cancer cells.
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Conteltinib
SY-707, CT-707
T149971384860-29-0In house
Conteltinib (CT-707) is an enzyme inhibitor with antitumor activity targeting FAK, ALK, and Pyk2.Conteltinib exhibits significant inhibition of FAK, overcomes hypoxia-mediated sorafenib resistance in hepatocellular carcinoma through inhibition of YAP signaling, and can be used in advanced ALK-positive non-small-cell lung cancer and lymphoma.
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6-8 weeks
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debio 0932
RGRN-305, MC2-32, CUDC-305, CUDC305, BEBT-305, BEBT305
T150881061318-81-7In house
Debio 0932 (CUDC-305) is a heat shock protein 90 (Hsp90) inhibitor that targets the n-terminal atp-binding pocket to promote apoptosis, and has the advantage of being orally available and able to cross the blood-brain barrier (BBB) for the treatment of cancers such as non-small-cell lung cancer (NSCLC) and neuroblastoma.
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7-10 days
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Olomoucine
T21588101622-51-9In house
Olomoucine is an ATP-competitive inhibitor of Cdk2 cyclin A, Cdc2 CyclinB, CDK2 CyclinE, CDK5 p35, and ERK1 p44 MAP kinase with IC50s of 7, 7, 7, 3, and 25 µM, respectively. It regulates the cell cycle and exhibits anti-melanin tumor activities.
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Cdc7-IN-7c
Cdc7 inhibitor-7c, Cdc7 inhibitor 7c, Cdc7 IN 7c
T238671330781-04-8In house
Cdc7-IN-7c (Cdc7 inhibitor-7c) has antitumor activity and has inhibitory effect on liver cancer, lung cancer, kidney cancer, brain cancer and cervical cancer.
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6-8weeks
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TargetMol | Inhibitor Sale
CID-5056270
T23888681173-76-2In house
CID-5056270 has anticancer activity and can inhibit lung cancer, anal cancer, bladder cancer, cervical cancer, vulvar cancer, penile cancer, Burkitt's lymphoma, breast cancer and bone cancer. It can be used to study hypertension, Alzheimer's disease and arteriosclerosis.
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6-8 weeks
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SDZ-62-434
SDZ62434, SDZ 62 434
T28740115621-95-9In house
SDZ-62-434, a platelet-activating factor inhibitor with antitumor activity, inhibits bombesin- and platelet-derived growth factor-induced DNA synthesis in quiescent Swiss 3T3 cells, making it a potential candidate for studying leukemia, human xenograft colorectal cancer, and lung cancer.
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6-8 weeks
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Antroquinonol
T300871010081-09-0In house
Antroquinonol is a ubiquinone derivative from Antrodia camphorata with anti-inflammatory and anticancer activities.Antroquinonol reduces oxidative stress and inhibits inflammation and sclerosis in mice with focal segmental glomerulosclerosis through enhancement of the Nrf2 signaling pathway.Antroquinonol has potential for use in the treatment of non-small cell lung cancer. Antroquinonol has potential for the treatment of non-small cell lung cancer and may be used in colon cancer research.
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6-8weeks
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XR 5944
XR5944, MLN 944, MLN-944, XR-5944, MLN944
T35187343247-32-5In house
XR 5944 is an antitumor compound that targets DNA, is a topoisomerase inhibitor, inhibits ER activity, and can be used to study colon and lung cancer.
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6-8 weeks
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